Significance* is a specialised pharma and academic consultancy, adding value to stakeholders by leading and supporting Evidence Generation Strategies and Real World Evidence initiatives, including RWE study design and execution.
With our extensive experience, we understand firsthand the challenges organizations face in navigating Real World Data to generate top class Real World Evidence and impactful evidence generation strategies. And we are here to help.
Our vision is a future where evidence-driven decisions lead to better health outcomes for patients worldwide.
Generate world class evidence that have an impact
We know first hand the challenges organizations phase on generating a comprehensive and effective evidence generation and strategy. Functional and geographical silos, lengthly processes, unclear frameworks and fragmented internal communication can have significant impact on the quality of the evidence generated as well as pressure resources and budget. Significance can provide expertise and guide you across the full spectrum of RWE initiatives and activities.
Real World Evidence Studies
Design, execution and supervision of RWE studies
Development and review of study documentation
Lead study execution and dissimination of results
Evidence Generation Strategy
Evidence strategy development & implementation
Tactics and integration of cross-functional needs
Development of framework for Evidence Strategies
Processes & RWE awareness
Design, implementation and communication of internal processes and SOPs for RWE
Educational activities and workshops for Real World Data and Evidence
Change management across stakeholders and functions
Evidence with purpose, Delivered
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From study design to dissemination, we provide end-to-end support for Real World Evidence studies. This includes protocol development, documentation, project management, and alignment with internal and external stakeholders. With a focus on strategic clarity and operational excellence, we help ensure your studies generate credible, impactful results that can be published and effectively communicated to key audiences.
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We support the development and execution of Integrated Evidence Generation strategies that align priorities across funtions and geographies. By fostering cross-functional collaboration and long-term value, we help shape clear, actionable plans that guide Real World Evidence efforts across the product lifecycle. We help shape strategies that drive better decisions by effective stakeholder management, aligning the right processes, and ensuring a clear path to measurable impact.
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With more than a decade of experience in cross-functional roles across multiple global pharma companies, I have created training sessions for Real World Evidence that focus on the tailored needs of your organization. Whether it’s the fundamentals of Evidence Generation, advanced Real World Evidence study designs, or specific RWE knowledge your team can benefit from, the sessions are built to deliver value. Successfully presented in multiple global companies to Medical, Commercial, Market Access, and Senior Management audiences.
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Clear, fit-for-purpose processes are essential to enable teams to work efficiently, stay aligned, and remain compliant. From drafting or refining procedures to aligning stakeholders, the goal is to reduce delays, support execution, and ensure your Medical, Access, and Commercial teams can focus on delivering value. With hands-on experience navigating internal processes in global pharma, I offer support to streamline your Real World Evidence-related SOPs and cross-functional workflows.
About Significance
Evangelos has started Significance after a decade of experience in global pharmaceutical companies, working in Clinical Trials, Real World Data analytics, leading multinational Real World Evidence studies and designing global evidence generation strategies and frameworks.
After working with multiple global companies and collaborating with world’s largest CROs and small consultancies, Evangelos developed an advisory service embodying the traits of an ideal partner: adaptable, understanding of client needs, willing to go the extra mile, and eager to share knowledge. He and Significance team is committed to offering insights, suggestions, and services before payment, avoiding generic solutions for tailored client support.
I started Significance after a decade of experience in global pharmaceutical companies, working in Clinical Trials, Real World Data analytics, leading multinational Real World Evidence studies and designing global evidence generation strategies and frameworks.
As a manager in pharma I hired and worked with a number of external support providers, from world’s largest CROs to small boutique consultancies. From those experiences, I decided to developed an advisory service embodying all the traits of an ideal partner: adaptable, understanding of client needs, willing to go the extra mile, and eager to share knowledge. He and Significance team is committed to offering insights, suggestions, and services before payment, avoiding generic solutions for tailored client support.
Elevating evidence generation for more than 10 years in global and regional functions
Let’s Connect!
Whether you got a Real World Evidence project in mind, need to strategise on your evidence generation or just curious about Real World Evidence and their impact, just drop a message and let’s discuss how we can drive impactful results together.